Publications

Authors:

Zuliani, Riccardo; Delvecchio, Giuseppe; Bonivento, Carolina; Cattarinussi, Giulia; Perlini, Cinzia; Bellani, Marcella; Marinelli, Veronica; Rossetti, MARIA GLORIA; Lasalvia, Antonio; Mcintosh, Andrew; Lawrie, Stephen M; Balestrieri, Matteo; Ruggeri, Mirella; Brambilla, Paolo

Title:

Increased gyrification in schizophrenia and non affective first episode of psychosis

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Schizophrenia Research

ISSN of journal:

0920-9964

N° Volume:

193

Page numbers:

269-275

Keyword:

first episode psychosis; gyrification; MRI; prefrontal cortex; schizophrenia

Short description of contents:

BACKGROUND: Prefrontal cortex gyrification has been suggested to be altered in patients with schizophrenia and first episode psychosis. Therefore, it may represent a possible trait marker for these illnesses and an indirect evidence of a disrupted underlying connectivity. The aim of this study was to add further evidence to the existing literature on the role of prefrontal gyrification in psychosis by carrying out a study on a sizeable sample of chronic patients with schizophrenia and non-affective first-episode psychosis (FEP-NA) patients. METHODS: Seventy-two patients with schizophrenia, 51 FEP-NA patients (12 who later develop schizophrenia) and 95 healthy controls (HC) underwent magnetic resonance imaging (MRI). Cortical folding was quantified using the automated gyrification index (GI). GI values were compared among groups and related to clinical variables. RESULTS: Both FEP-NA and patients with schizophrenia showed a higher mean prefrontal GI compared to HC (all p<0.05). Interestingly, no differences have been observed between the two patients groups as well as between FEP-NA patients who did and did not develop schizophrenia. CONCLUSIONS: Our results suggest the presence of a shared aberrant prefrontal GI in subjects with both schizophrenia and first-episode psychosis. These findings support the hypothesis that altered GI represents a neurodevelopmental trait marker for psychosis, which may be involved in the associated neurocognitive deficits.

Web page:

https://doi.org/10.1016/j.schres.2017.06.060

Product ID:

101733

Handle IRIS:

11562/976538

Last Modified:

November 16, 2022

Bibliographic citation:

Zuliani, Riccardo; Delvecchio, Giuseppe; Bonivento, Carolina; Cattarinussi, Giulia; Perlini, Cinzia; Bellani, Marcella; Marinelli, Veronica; Rossetti, MARIA GLORIA; Lasalvia, Antonio; Mcintosh, Andrew; Lawrie, Stephen M; Balestrieri, Matteo; Ruggeri, Mirella; Brambilla, Paolo, Increased gyrification in schizophrenia and non affective first episode of psychosis «Schizophrenia Research» , vol. 193 , 2018 , pp. 269-275

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