Publications

Authors:

Bonvicini, Cristian; Minelli, Alessandra; Scassellati, Catia; Bortolomasi, Marco; Segala, Matilde; Sartori, Riccardo; Giacopuzzi, Mario; Gennarelli, Massimo

Title:

Serotonin transporter gene polymorphisms and treatment-resistant depression

Year:

2010

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Progress in Neuro Psychopharmacology

ISSN of journal:

0278-5846

N° Volume:

34

Page numbers:

934-939

Keyword:

rs25531; SLC6A4; Treatment-resistant depression; 5-HTTLPR

Short description of contents:

Major Depression Disorder (MDD) is a serious mental illness that is one of the most disabling diseases worldwide. In addition, approximately 15% of depression patients are defined treatment-resistant (TRD). Preclinical and genetic studies show that serotonin modulation dysfunction exists in patients with TRD. Some polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) are likely to be involved in the pathogenesis/treatment of MDD; however, no data are available concerning TRD.Therefore, in order to investigate the possible influence of SLC6A4 polymorphisms on the risk of TRD, we genotyped 310 DSM-IV MDD treatment-resistant patients and 284 healthy volunteers. We analysed the most studied polymorphism 5-HTTLPR (L/S) and a single nucleotide substitution, rs25531 (A/G), in relation to different functional haplotype combinations. However the correct mapping of rs25531 is still debated whether it is within or outside the insertion. Our sequencing analysis showed that rs25531 is immediately outside of the 5-HTTLPR segment.Differences in 5-HTTLPR allele (p = 0.04) and in L allele carriers (p < 0.05) were observed between the two groups. Concerning the estimated haplotypes analyses, LALA homozygote haplotype was more represented among the control subjects (p = 0.01, OR = 0.64 95%CI: 0.45 - 0.91). In conclusion, this study reports a protective effect of the LALA haplotype on TRD, supporting the hypothesis that lower serotonin transporter transcription alleles are correlated to a common resistant depression mechanism.

Product ID:

58768

Handle IRIS:

11562/347485

Deposited On:

February 10, 2012

Last Modified:

November 9, 2022

Bibliographic citation:

Bonvicini, Cristian; Minelli, Alessandra; Scassellati, Catia; Bortolomasi, Marco; Segala, Matilde; Sartori, Riccardo; Giacopuzzi, Mario; Gennarelli, Massimo, Serotonin transporter gene polymorphisms and treatment-resistant depression «Progress in Neuro Psychopharmacology» , vol. 34 , 2010 , pp. 934-939

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