Publications

Authors:

Calzavara-Pinton, P; Fabbrocini, G; Girolomoni, G; Matiucci, A; Micali, G; Musumeci, Ml; Patruno, C; Pellacani, G; Rossi, Mt; Castello, M; Stingeni, L8.

Title:

Topical tacrolimus in adult atopic dermatitis: a consensus based on a 15-year experience

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

ISSN of journal:

0392-0488

N° Volume:

155

Number or Folder:

1

:

Edizioni Minerva Medica:Corso Bramante 83-85, 10126 Turin Italy:011 39 011 678282318, EMAIL: journals.dept@minervamedica.it, INTERNET: http://www.minervamedica.it, Fax: 011 39 011 674502

Page numbers:

8-13

Keyword:

Dermatitis, atopic; Calcineurin inhibitors; Tacrolimus; Lymphoma;; Skin neoplasms; Administration, topical

Short description of contents:

Atopic dermatitis (AD) is one of the most common cutaneous inflammatory diseases both in adults and in children. It is a chronic, remitting-relapsing dermatitis, primarily managed by dermatologists, but also by allergists and primary care physicians. Due to coexistence of comorbidities, often a multidisciplinary team is required. Topical calcineurin inhibitors (TCIs - i.e. tacrolimus and pimecrolimus) are a class of steroid-sparing, anti-inflammatory agents that have been shown to be efficacious for the treatment of AD acute flares and in maintenance therapy. In particular, the application of tacrolimus ointment twice daily reduces AD severity and pruritus. Moreover, maintenance therapy with an intermittent application of tacrolimus to recurrent skin sites (proactive therapy) decreases frequency and severity of relapses. Many studies have also assessed the efficacy of TCIs in disorders other than AD. Although US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) issued a “black box warning” regarding the possible cancerogenic activity of these drugs, there is currently no strong evidence of an increased rate of malignancy in treated patients, and observational data from postmarketing surveillance studies have shown no safety concerns. A panel of dermatologists have thoroughly discussed the use of tacrolimus in AD after 15-year experience. The experts focused on AD flare treatment, maintenance therapy and management of side effects. Consensus was reached on some areas of interest, namely the stages of AD in which tacrolimus is recommended, the amount of drug to be applied, how to manage side effects, and how to improve patient’s compliance. Moreover, the panel of experts recommended to perform randomized clinical trials to confirm the efficacy of tacrolimus off-label use, which led to successful outcomes in other skin diseases.

Product ID:

113123

Handle IRIS:

11562/1012429

Last Modified:

October 30, 2024

Bibliographic citation:

Calzavara-Pinton, P; Fabbrocini, G; Girolomoni, G; Matiucci, A; Micali, G; Musumeci, Ml; Patruno, C; Pellacani, G; Rossi, Mt; Castello, M; Stingeni, L8., Topical tacrolimus in adult atopic dermatitis: a consensus based on a 15-year experience «GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA» , vol. 155 , n. 1 , 2020 , pp. 8-13

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo